By R T Blickenstaff
Antitumor Steroids examines using steroids, in addition to nonsteroidal antiestrogens and a few benzo[a]carbazoles, within the therapy of melanoma. It explains the mechanism through which steroids and their receptors interact to impact their physiological services in most cases and their antitumor task specifically. It additionally describes the systematic screening of antitumor compounds remoted from typical assets.
Organized into 9 chapters, this ebook starts with an summary of the position of steroids in melanoma remedy. It then discusses the estrogens, antiestrogens, and compounds (all containing an fragrant A-ring). the subsequent chapters examine androgens, a few antiandrogens, derivatives in keeping with C-19 steroids, progestins and corticoids, bile acids, and compounds with a side-chain carboxyl team. The e-book explains the biogenesis and metabolism of androgens; the pharmacology of medroxyprogesterone acetate; the antitumor houses of obviously happening corticosteroids; sterols and cucurbitacins; diet D and its metabolites; and cardenolides, bufadienolides, and withanolides. The e-book concludes with a bankruptcy on bile acids, sapogenins and its analogs, and miscellaneous steroids.
This ebook is a priceless source for natural and medicinal chemists biochemists, and pharmacologists attracted to using steroids in treating melanoma.