Download Nuclear Magnetic Resonance and Nucleic Acids by Thomas L. James (Eds.) PDF

By Thomas L. James (Eds.)

The significantly acclaimed laboratory usual for 40 years, Methods in Enzymology is without doubt one of the such a lot hugely revered courses within the box of biochemistry. due to the fact that 1955, each one quantity has been eagerlyawaited, usually consulted, and praised via researchers and reviewers alike. greater than 250 volumes were released (all of them nonetheless in print) and lots more and plenty of the cloth is appropriate even today--truly an important e-book for researchers in all fields of lifestyles sciences

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For D N A fragments, the choice is relatively easy, since any right-handed doublehelical crystal structure is a good structural approximation. For initial M A R D I G R A S calculations, we typically utilize canonical B- and A-DNA models, energy-minimized for the respective nucleotide sequence (vide supra). As already described, M A R D I G R A S will refine a hybrid relaxation matrix until a user-defined threshold is reached for the iteration, defined by a sixth-root residual index, RX: [(ao)i 1/6 -- (ac)il/6 I RX ~ l ~ .

Egan, and T. L. James, Biochemistry 33, 354 (1994); (6) K. D. Bishop, F. Blocker, W. Egan, and T. L. James, Biochemistry 33, 427 (1994); (7) A. Mujeeb, S. M. Kerwin, W. Egan, G. L. Kenyon, and T. L. James, Biochemistry 31, 9325 (1992); (8) M. Tonelli and T. L. James, unpublished results (1995); (9) C, Gonzalez, W. Stec, A. Kobylanska, R. I. Hogrefe, M. Reynolds, and T. L. James, Biochemistry 33, 11062 (1994). type of COSY technique, where spectra are recorded for individual peaks, results in much higher digital resolution and ultimately in narrower error margins for the coupling constants.

We note that the accuracy of integrated peak intensities and general spectral quality is worse for 1H20 datasets. Consequently, one might be tempted to commingle the additional cross-peaks involving exchangeable protons from ~H20 spectra, with the higher quality data obtained from 2H20 solutions. Aside from surmountable normalization problems, however, the fundamental problem is that cross45 K. Weisz, R. H. Sharer, W. Egan, and T. L. James, Biochemistry 31, 7477 (1992). 46 K. D. Bishop, F. Blocker, W.

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