By William J. Marshall MA PhD MSc MBBS FRCP FRCPath FRCPEdin FRSB FRSC, Márta Lapsley MB BCh BAO MD FRCPath, Andrew Day MA MSc MBBS FRCPath, Ruth Ayling PhD FRCP FRCPath
Now totally revised and up to date, scientific Biochemistry, 3rd variation is key studying for strong point trainees, rather these getting ready for postgraduate examinations. it's also a useful present reference for all demonstrated practitioners, together with either clinical and scientist scientific biochemists.
Building at the good fortune of earlier versions, this major textbook basically specializes in scientific elements of the topic, giving particular insurance of all stipulations the place scientific biochemistry is utilized in analysis and administration - together with dietary problems, diabetes, inherited metabolic ailment, metabolic bone disorder, renal calculi and dyslipidaemias. the purchase and interpretation of medical biochemical facts also are mentioned in detail.
Expanded sections on haematology and immunology for medical biochemists offer an intensive knowing of either laboratory and medical aspects
New chapters are incorporated on very important evolving parts equivalent to the metabolic reaction to emphasize, forensic elements of scientific biochemistry and knowledge caliber management
An prolonged editorial group - together with 3 specialist new additions - guarantees accuracy of data and relevance to present curricula and scientific practice
A fabulous new accompanying digital model offers an more suitable studying adventure and swift reference every time, anywhere!
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Additional resources for Clinical Biochemistry : Metabolic and Clinical Aspects
Example text
Aldosterone acts through the specific nuclear mineralocorticoid receptor, which is protected from cortisol (for which it has equal affinity) through the intracellular production of 11β-hydroxysteroid dehydrogenase (11βHSD). This enzyme converts cortisol to cortisone, for which the receptor has weak affinity. The response within the principal cells lining the distal tubules and collecting ducts is the apical influx of sodium via epithelial Na+ channel (ENaC) stimulation and its efflux via basolateral Natriuretic peptides.
Fraser CG, Fogarty Y. Interpreting laboratory results. Br Med J 1989;298:1659–60. Although written some 23 years ago for a general medical readership, this leading article is still worth reading. It was one of the first general articles to draw attention to the importance of taking analytical and biological variation into account when interpreting laboratory data. Galen RS, Gambino SR. Beyond normality: the predictive value and efficiency of medical diagnoses. New York: John Wiley; 1975. The seminal text on the predictive value concept.
Three exons code for a 151 AA peptide (preproANP) which, following removal of the signal peptide, results in a 126 AA peptide (proANP) – the main storage form. On secretion into the circulation, proANP is cleaved into the N-terminal 1–98 peptide (NT-proANP), and the biologically active 99–126 peptide (ANP). The major stimulus to the secretion of ANP is atrial stretch and the major sites of synthesis are the atria. In 1988, a second natriuretic peptide was identified, in porcine brain, and termed brain natriuretic peptide (BNP).