By Desmond J. Brown, Jonathan A. Ellman, Edward C. Taylor
This ebook offers the main complete, present reference at the man made chemistry of cinnolines and phthalazines. purposes to the syntheses of average items and different chiral compounds are defined. quantity sixty four comprises chapters exploring the subsequent topics:
* fundamental Syntheses of Cinnolines
* Cinnoline, Alklycinnolines, and Arylcinnolines
* Halogenocinnolines
* Oxycinnolines
* Thiocinnolines
* Nitro-, Amino-, and similar Cinnolines
* Cinnolinecarboxylic Acids and comparable Derivatives
* basic Syntheses of Phthalazines
* Phthalazine, Alklyphthalazines, and Arylphthalazines
* Halogenophthalazines
* Oxyphthalazines
* Thiophthalazines
* Phthalazinecarboxylic Acids and similar Derivatives
* An Appendix of Tables of easy Cinnolines and straightforward Phthalazines
Read Online or Download Cinnolines and Phthalazines, Supplement II (The Chemistry of Heterocyclic Compounds, Volume 64) PDF
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Extra resources for Cinnolines and Phthalazines, Supplement II (The Chemistry of Heterocyclic Compounds, Volume 64)
Example text
1) at the end of this book. More notable studies on the physical properties of cinnoline or reduced cinnoline are indicated briefly here. Aromaticity. 527 Complexes. 1030 Electron Spin Resonance. 806 Energy Calculations. 813 Cinnoline 35 Nuclear Magnetic Resonance Studies. 152 Ultraviolet/Visible Spectra. 3. Reactions of Cinnoline Only a few reactions of unsubstituted cinnoline have been reported since 1972. They are illustrated here. 217,cf. 2. ALKYL- AND ARYLCINNOLINES (H 6, 13, 39; E 18) This section covers both C- and N-alkyl/arylcinnolines as well as alkyl/ arylcinnolinium salts.
However, X-ray analyses have been reported for 4-methylcinnoline,630 6-chloro-2-p-chlorophenyl-8-(trans-1,2-diphenylvinyl)-3,4-diphenyl-2,3-dihydrocinnoline,722,749 and two analogs thereof;749 the MS (mass spectral) fragmentation of 1-methyl-4,4-diphenyl-1,2,3,4-tetrahydro- Alkyl- and Arylcinnolines 37 cinnoline has been studied,756 and a few preparative methods and reactions have been reported, as illustrated in the subsections that follow. 1. Preparation of Alkyl- and Arylcinnolines Many alkyl/aryl cinnolines have been made by primary syntheses (see Chapter 1), and several diverse preparative procedures are illustrated in the following classified examples.
2. Reactions of Alkyl- and Arylcinnolines Reactions that involve alkyl/aryl groups attached to cinnolines, or that involve modification of the cinnoline nucleus of alkyl/arylcinnolines bearing no other groups, are exemplified here. 829 (69) Me CHAPTER 3 Halogenocinnolines (H 29; E 121) An extraordinary paucity of fresh data on all aspects of halogenocinnolines in the 1972–2004 literature is reflected in the brevity of treatment accorded here to these important compounds. Halogeno substituents at the 3- or 4-position of cinnoline are appreciably activated by N2 and N1, respectively; those at positions 5–8 or an extranuclear position have activities only marginally better than those in corresponding carbocyclic compounds.