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Additional resources for Anxiety and Substance Use Disorders: The Vicious Cycle of Comorbidity (Series in Anxiety and Related Disorders)
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Positive feedback between self-medication and withdrawal can thus sustain co-morbidity of SUD and anxiety disorder. Consistent with the epidemiological conclusions of Kushner et al. (this volume), neurobiology suggests multiple causal routes (particularly via stress systems) to co-morbidity of SUD and anxiety. Life events (and particularly their associated cognition) can impact on the settings of biological systems (Kendler, Thornton, & Gardner, 2000). Equally, disorders such as anxiety and depression can alter, adversely, the incidence of particular classes of life events (Harkness, Monroe, Simons, & Thase, 1999).