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Enantioselective artificial tools should not in simple terms within the leading edge of chemical and pharmaceutical learn yet task during this sector is consistently expanding. it really is influenced through the urgency to acquire medicinal drugs or compounds of medicinal curiosity as unmarried anantiomers, and the keeness to synthesize typical items in nonracemic shape. This quantity offers seven chapters from pioneers and gurus during this swiftly increasing box.

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Plant Physio. Plant Mol. Bio. 1988,39, 23; Chen, S. C. Chem. Can. 1983,35,13. The review on the side chain synthesis of steroids: Piatak, D. ; Wicha, J. Chem. Rev. 1978, 78, 199. Snider, B. ; Straten, J. W van J. Org. Chem. 1979,44, 3567. -R; Nakai, T. J. Chem. Soc, Chem. Commun. 1988,1430. ; Tidd, B. ; Turner, W. ; J. Chem. Soc. 1963,5385; Ellis, J. ; Stodola, F. ; Vesonder, R. F ; Glass, C. A. ; Tidd, B. ; Turner, W. B. Aust. J. Chem. 1967,18, 373. For syntheses: (a) Schreiber, S. ; Hoveyda, A.

J. Phys. (Paris) 1984,3, 393; Shubnikov, A. V; Koptsik, V. A. Symmetry in Science and Art; Plenum Press: New York, 1974; Hoye, T. ; Peck, D. ; Swanson, T. A. J. Am. Chem. Soc. ; Siegel, J. J. Am. Chem. Soc. 1984,106, 3319. 53. Kagan, H. ; Fiaud, J. C. In Topics in Stereochemistry; Eliel, E. L. ; Interscience: New York, 1988; p. 249; Brown, J. M. Chem. & Ind. 1988, 612. 54. ; Peterson, J. ; Sita, L. R. Angew. , Int. Ed. Engl. 1985, 24, 1; Heathcock, C. H. In Asymmetric Synthesis; Morrison, J. D.

In the desymmetrization by enantiofacial selective C-C bond formations, at least two new chiral centers are generated. , 5S)-syn-product is obtained in >99% ee with more than 99% diastereoselectivity. The importance of desymmetrization is exemplified by the synthesis of a potential intermediate for isocarbacycline (Scheme 35). t (53%) ^ > 99% syn >99 (99% ee) Scheme 34. Asymmetric Carbonyl-Ene Reactions *g 29 (*)-i (10mol%) H V-4^ + H^C02CH3" MS4A -30 °C (100%) ^i) °* H^ C02CH3 96% de (99% ee) Scheme 35.

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