Download ACM transactions on information systems (January) by Association for Computing Machinery PDF

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Within one library, up to 80% of the unique tags have a frequency of 1, but these make up about 20% of the total number of copies of tags. Some of the single frequency tags represent genuine low frequency mRNAs. However, it is impossible to tell which of the single frequency tags are errors by only looking at a single library. Since the size of the set of possible tags is 410 ≈ 106 , and only about 3 × 105 of these tags have ever appeared in any library, a sequence error in a tag most likely represents a completely new tag that never appears in any other library.

Such an approach has the potential to determine new prognostic and diagnostic biomarkers in addition to new gene targets for therapeutic intervention. 1 Background Cancers are typically classified based on macroscopic qualities such as the tissues they developed in. However, the same type of cancer can have different reactions to treatment in different people, and on the other hand, one treatment can be effective for cancers originating in different tissues. A possible explanation for these observations is that cancers, which are similar on a macroscopic level, may in fact be different at the sub-cellular level, and that certain cancers that originate in different tissues may actually be similar to each other at the sub-cellular level.

1, January 2005. A Methodology for Analyzing SAGE Libraries for Cancer Profiling • 45 The weak clustering result is consistent with our preliminary results using CLARANS and indicates that we have to address the problem of missing values due to incomplete sequencing and suitable subspace selection. 4 Missing Tag Imputation After the outlined error removal, the total number of tag copies in a library varies from 1293 to 79498. Consider all the libraries whose total tag counts are below 30,000. Out of the 88, there are 28 such libraries.

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